Nominations for Strategies for Identifying and Addressing Vulnerabilities Posed by Synthetic Biology

View study website here: nas.edu/synthetic-biology

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Charge to the Committee
To assist the U.S. Department of Defense's Chemical and Biological Defense Program (CBDP), The National Academies of Sciences, Engineering, and Medicine will appoint an ad hoc committee to address the changing nature of the biodefense threat in the age of synthetic biology. Specifically, the focus of the study will be the manipulation of biological functions, systems, or microorganisms resulting in the production of a disease-causing agent or toxin. The study will be conducted in two primary phases. Initially, the committee will develop a strategic framework to guide an assessment of the potential security vulnerabilities related to advances in biology and biotechnology, with a particular emphasis on synthetic biology.

The framework will focus on how to address the following three questions: What are the possible security concerns with regard to synthetic biology that are on the horizon? What are the time frames of development of these concerns? What are our options for mitigating these potential concerns? The committee will publish a brief interim, public report outlining the developed framework. This framework will not be a threat assessment, but rather, will focus on ways to identify scientific developments to enable opportunities that have the potential to mitigate threats posed by synthetic biology in the near-, mid-, and long-term, with the specific time frames defined by the committee. The framework will lay out how best to consider the trajectory of scientific advances, identify potential areas of vulnerability and predict promising mitigation opportunities.

In Phase 2 of the study, the committee will use the outlined strategic framework to generate an assessment of vulnerabilities posed by synthetic biology. Inputs to this assessment may include information about the current threat, current program priorities and research and an evaluation of the current landscape of science and technology. Conclusions and recommendations will include a list and description of vulnerabilities posed by synthetic biology and prioritized options to address them.

Expertise Needed 
A committee of approximately 10-12 experts will be appointed by the Academies, drawing members from the academic, industrial, and non-profit sectors.  Expertise on the committee is expected to include the following areas: synthetic biology, microbiology, chemical engineering, biosecurity, technical forecasting, genetic engineering, molecular biology, chemistry, threat assessment, threat characterization, research planning, modeling, data analytics, biotechnology, biodefense, bioinformatics, and biodesign software. Individuals with other expertise relevant to the charge will also be considered.
 
To make a nomination, send us the person’s name, affiliation, contact information, area of expertise, and a brief statement on why the person is relevant to the study topic. While this information is helpful, the only required field in this survey is the nominee's name. If you would like to email your nominee instead of using this form, please email SynBioDefense@nas.edu.

Please submit your nominations by Monday, October 3rd, 2016 for full consideration. All nominations submitted after that time will be considered on an ad hoc basis.